Kev Taw Qhia Txog Cov Tshuaj Toxic Ntawm Organophosphorus

Kev ua ntawm feem ntau ntawm cov hlab ntsha cholinergic hauv tib neeg lub cev (xws li preganglionic fibers ntawm lub cev muaj zog sympathetic thiab parasympathetic qab haus huv, postganglionic fibers ntawm cov hlab ntsha parasympathetic thiab qee cov hlab ntsha sympathetic) tso siab rau kev tso tawm ntawm acetylcholine ntawm qhov sib txuas ntawm nws cov terminals. cell innervate lub cev muaj zog. Acetylcholine tseem koom nrog hauv kev sib kis ntawm impulses ntawm cov paj hlwb hauv qee qhov chaw ntawm lub hauv nruab nrab paj hlwb, xws li lub cev muaj zog ntawm lub paj hlwb cortex, tshwj xeeb tshaj yog cov pyramidal hlwb hauv qhov tob cortex, caudate nucleus thiab thalamus. Kev sib kis ntawm cov hlab ntsha cholinergic yuav tsum tau ua ke nrog cholinergic receptors los tsim cov teebmeem. Cholinergic receptors muab faib ua muscarinic thiab nicotinic hom; tus qub yog faib nyob rau hauv lub myocardial du nqaij qog innervated los ntawm cholinergic postganglionic fibers Sib npaug lub cev, lub tom kawg yog faib nyob rau hauv lub autonomic ganglia thiab lub cev muaj zog endplate ntawm skeletal nqaij. Nyob rau hauv ib txwm muaj xwm txheej, cov acetylcholine tso tawm sai sai decomposed los ntawm acetylcholinesterase tam sim no nyob rau hauv cov ntaub so ntswg tom qab ua tiav nws physiological muaj nuj nqi thiab poob nws cov nyhuv.

Tom qab cov organophosphorus nkag mus rau hauv tib neeg lub cev, nws pawg phosphoryl yog covalently ua ke nrog cov active ib feem ntawm lub enzyme tsim phosphorylated cholinesterase, thiab lub peev xwm mus decompose acetylcholine poob, thiaj li hais tias ib tug loj npaum li cas ntawm acetylcholine accumulates nyob rau hauv lub cev thiab inhibits tus xwb. kev ua ntawm acetylcholinesterase, ua rau hauv nruab nrab Lub paj hlwb thiab cov hlab ntsha cholinergic dhau lawm -zoo siab, thiab thaum kawg mus rau kev nyuaj siab thiab tsis ua haujlwm, qhia txog cov tsos mob thiab cov tsos mob.